When Channel Bonding is Beneficial for Opportunistic Spectrum Access Networks

Transmission over multiple frequency bands combined into one logical channel speeds up data transfer for wireless networks. On the other hand, the allocation of multiple channels to a single user decreases the probability of finding a free logical channel for new connections, which may result in a network-wide throughput loss. While this relationship has been studied experimentally, especially in the WLAN configuration, little is known on how to analytically model such phenomena. With the advent of Opportunistic Spectrum Access (OSA) networks, it is even more important to understand the circumstances in which it is beneficial to bond channels occupied by primary users with dynamic duty cycle patterns. In this paper we propose an analytical framework which allows the investigation of the average channel throughput at the medium access control layer for OSA networks with channel bonding enabled. We show that channel bonding is generally beneficial, though the extent of the benefits depend on the features of the OSA network, including OSA network size and the total number of channels available for bonding. In addition, we show that performance benefits can be realized by adaptively changing the number of bonded channels depending on network conditions. Finally, we evaluate channel bonding considering physical layer constraints, i.e. throughput reduction compared to the theoretical throughput of a single virtual channel due to a transmission power limit for any bonding size.Comment: accepted to IEEE Transactions on Wireless Communication

Au Nanomatryoshkas as Efficient Near-Infrared Photothermal Transducers for Cancer Treatment: Benchmarking against Nanoshells

Au nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of this process is nanoparticle size, which influences both tumor uptake and photothermal efficiency. Here, we report a direct comparative study of ∼90 nm diameter Au nanomatryoshkas (Au/SiO2/Au) and ∼150 nm diameter Au nanoshells for photothermal therapeutic efficacy in highly aggressive triple negative breast cancer (TNBC) tumors in mice. Au nanomatryoshkas are strong light absorbers with 77% absorption efficiency, while the nanoshells are weaker absorbers with only 15% absorption efficiency. After an intravenous injection of Au nanomatryoshkas followed by a single NIR laser dose of 2 W/cm2 for 5 min, 83% of the TNBC tumor-bearing mice appeared healthy and tumor free >60 days later, while only 33% of mice treated with nanoshells survived the same period. The smaller size and larger absorption cross section of Au nanomatryoshkas combine to make this nanoparticle more effective than Au nanoshells for photothermal cancer therapy